Project Options

AI for Cancer Detection
Identifying Cancer Cells and Their Biomarker Expressions
Cell quantitation techniques are used in biomedical research to diagnose and treat cancer. Current quantitation methods are subjective and based mostly on visual impressions of stained tissue samples. This time-consuming process causes delays in therapy that reduce the effectiveness of treatments and add to patient distress. Our lab is developing computational algorithms that use deep learning to model changes in protein structure from multispectral observations of tissue. Once computed, the model can be applied to any tissue observation to detect a variety of protein markers without further spectral analysis. The deep learning model will be quantitatively evaluated on a learning dataset of cancer tumors.

AI for Neuroscience
Deep Learning for Diagnosing and Treating Neurological Disorders
Advances in biomedical research are based upon two foundations, preclinical studies using animal models, and clinical trials with human subjects. However, translation from basic animal research to treatment of human conditions is not straightforward. Preclinical studies in animals may not replicate across labs, and a multitude of preclinical leads have failed in human clinical trials. Inspired by recent generative models for semi-supervised action recognition and probabilistic 3D human motion prediction, we are developing a system that learns animal behavior from unstructured video frames without labels or annotations. Our approach extends a generative model to incorporate adversarial inference, and transformer-based self-attention modules.

AI for Multimodal Data & Document Analysis
Deciphering Findings from the Tulsa Race Massacre Death Investigation
The Tulsa Race Massacre (1921) destroyed a flourishing Black community and left up to 300 people dead. More than 1000 homes were burned and destroyed. Efforts are underway to locate the bodies of victims and reconstruct lost historical information for their families. Collaborating with the Tulsa forensics team, we are developing spectral imaging methods (on-site) for deciphering information on eroded materials (stone engravings, rusted metal, and deteriorated wood markings), and a novel multimodal transformer network to associate recovered information on gravestones with death certificates and geographical information from public records.

AI for Quantum Physics & Appearance Modeling
Quantum Level Optical Interactions in Complex Materials
The wavelength dependence of fluorescence is used in the physical sciences for material analysis and identification. However, fluorescent measurement techniques like mass spectrometry are expensive and often destructive. Empirical measurement systems effectively simulate material appearance but are time consuming, requiring densely sampled measurements. Leveraging GPU processing and shared super computing resources, we develop deep learning models that incorporate principles from quantum mechanics theory to solve large scale many-body problems in physics for non-invasive identification of complex proteinaceous materials.